Substance
What not to mix with MXE
Dissociative
Also calledmethoxetamine
Summary
MXE is checked against 40 other substances — 12 dangerous, 2 unsafe and 12 caution.
Dangerous
12- MXE and AlcoholThere is a high risk of memory loss, vomiting and severe ataxia from this combination.
- MXE and AMTHigh risk of death or life-changing injury. Do not combine.
- MXE and BuprenorphineThis combination can potentiate the effects of the opioid
- MXE and CodeineThis combination can potentiate the effects of the opioid
- MXE and DiphenhydramineThere is a high risk of serotonin syndrome from this combination. Both substances potentiate the ataxia and sedation caused by the other and can lead…
- MXE and FentanylThis combination can potentiate the effects of the opioid
- MXE and GHB / GBLBoth substances cause ataxia and bring a risk of vomiting and unconsciousness. If the individual falls unconscious while under the influence there is…
- MXE and KratomThis combination can potentiate the effects of the opioid
- MXE and LithiumThere is a risk of serotonin syndrome when combining Lithium with MXE, as Lithium can induce serotonin syndrome in conjunction with other…
- MXE and MethadoneThis combination can potentiate the effects of the opioid
- MXE and OpioidsThis combination can potentiate the effects of the opioid
- MXE and TramadolHigh risk of death or life-changing injury. Do not combine.
Unsafe
2- MXE and DXMThere is a risk of serotonin syndrome when combining DXM with MXE, due to DXM and MXE both being SRI’s. MXE and DXM having notable affinities for the…
- MXE and MAOIsMAO-B inhibitors appear to increase the potency of MXE. MAO-A inhbitors have some negative reports associated with the combination but there isn't…
Caution
12- MXE and 2C-T-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- MXE and AmphetaminesRisk of tachycardia, hypertension, and manic states
- MXE and BenzodiazepinesBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the…
- MXE and CocaineStimulants taken with MXE can lead to hypermanic states much more easily, especially if sleep is avoided.
- MXE and DOxAs an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
- MXE and MDMAThere have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience…
- MXE and MephedroneThe stimulant masks the depth of dissociation and encourages redosing; additive cardiovascular strain.
- MXE and MethamphetamineRisk of tachycardia, hypertension, and manic states
- MXE and NBOMesAs an NMDA antagonist MXE potentiates NBOMes which can be unpleasantly intense
- MXE and PCPThere are no reports available about this combination
- MXE and PregabalinPregabalin and MXE may synergize and increase each other’s negative side effects such as nausea, dizziness, and loss of consciousness. Caution is…
- MXE and SSRIsDepending on the SSRI this combination can be unpredictable
Low / synergy
9Low / no synergy
5Checking more than one?
This page rates MXE against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open MXE in the checkerOther dissociatives
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.