Combination

Mixing Caffeine and Ketamine

StimulantDissociative
Caffeine also called
coffee, energy drink, espresso, pre-workout
Ketamine also called
ket, special k, kitty, kittens
Verdict

Low risk, no synergy

No unexpected interactions.

Can you mix Caffeine and Ketamine?

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

Caffeine withWhat not to mix with Caffeine →
Ketamine withWhat not to mix with Ketamine →
All combinations →

Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.