Mixing Codeine and Tramadol
- Codeine also called
- lean, purple drank, co-codamol, dihydrocodeine
- Tramadol also called
- tram, ultram
Dangerous
Concomitant use of tramadol increases the seizure risk in individuals taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Codeine and Tramadol?
High risk of death or life-changing injury. Do not combine.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.
- Codeine
- Weak, but metabolised unpredictably between people
- Tramadol
- Opioid plus serotonin reuptake inhibition, and seizure risk
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.