Combination

Mixing DXM and Ketamine

DissociativeDissociative
DXM also called
robo, robitussin, robotussin, syrup, dex, cough syrup
Ketamine also called
ket, special k, kitty, kittens
Verdict

Low risk, increased effect

Both substances primarily exert their effects through NMDA antagonism. Currently, there is no evidence regarding mechanisms that might reduce these effects.

Can you mix DXM and Ketamine?

Low risk of harm, but the effects amplify each other. Doses that are fine alone can be far too much together.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

DXM withWhat not to mix with DXM →
Ketamine withWhat not to mix with Ketamine →
All combinations →

Rated low / synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.