Combination

Mixing Alcohol and Tramadol

DepressantOpioid
Alcohol also called
booze, beer, wine, liquor, ethanol, etoh
Tramadol also called
tram, ultram
Verdict

Dangerous

Heavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the affected individual in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.

Risk / Physical

The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.

Can you mix Alcohol and Tramadol?

High risk of death or life-changing injury. Do not combine.

Tramadol
Opioid plus serotonin reuptake inhibition, and seizure risk
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.