Combination

Mixing Cannabis and SSRIs

DepressantAntidepressant
Cannabis also called
weed, pot, marijuana, thc, hash, edibles
SSRIs also called
ssri, zoloft, sertraline, lexapro, escitalopram, prozac
Verdict

Low risk, no synergy

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Can you mix Cannabis and SSRIs?

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

Cannabis withWhat not to mix with Cannabis →
SSRIs withWhat not to mix with SSRIs →
All combinations →

Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.