Substance
What not to mix with Cannabis
Depressant
Also calledweed, pot, marijuana, thc, hash, edibles
Summary
Cannabis is checked against 40 other substances — 14 caution.
Caution
14- Cannabis and 2C-T-xCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Cannabis and 2C-xCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Cannabis and 5-MeO-xxTCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Cannabis and AmphetaminesStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Cannabis and AMTCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Small amounts can reduce nausea with aMT but take care.
- Cannabis and CocaineStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Cannabis and DiphenhydramineBoth can produce confusion and, at higher doses, hallucination. Together they commonly produce more disorientation and anxiety than either alone.
- Cannabis and DMTCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Cannabis and DOxCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Cannabis and LSDCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Cannabis and MescalineCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Cannabis and MethamphetamineStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Cannabis and MushroomsCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Cannabis and NBOMesCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Low / synergy
20Low / decrease
1Low / no synergy
5Checking more than one?
This page rates Cannabis against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Cannabis in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.