Combination

Mixing Cocaine and SSRIs

StimulantAntidepressant
Cocaine also called
coke, crack, blow, snow, yayo
SSRIs also called
ssri, zoloft, sertraline, lexapro, escitalopram, prozac
Verdict

Low risk, no synergy

May reduce each others' effectiveness. Cocaine can reduce mental stability and therefore exacerbate conditions which SSRIs are used to treat.

Can you mix Cocaine and SSRIs?

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

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Related combinations

Cocaine withWhat not to mix with Cocaine →
SSRIs withWhat not to mix with SSRIs →
All combinations →

Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.