Substance
What not to mix with Cocaine
Stimulant
Also calledcoke, crack, blow, snow, yayo
Summary
Cocaine is checked against 40 other substances — 7 dangerous, 11 unsafe and 15 caution.
Dangerous
7- Cocaine and AMTHigh risk of death or life-changing injury. Do not combine.
- Cocaine and BuprenorphineStimulants increase respiration rate allowing for a higher dose of opiates than normal. If the stimulant wears off first then the opiate may overcome…
- Cocaine and CodeineStimulants increase respiration rate allowing for a higher dose of opiates than normal. If the stimulant wears off first then the opiate may overcome…
- Cocaine and KratomStimulants increase respiration rate allowing for a higher dose of opiates than normal. If the stimulant wears off first then the opiate may overcome…
- Cocaine and MAOIsThis combination is poorly explored
- Cocaine and OpioidsStimulants increase respiration rate allowing for a higher dose of opiates than normal. If the stimulant wears off first then the opiate may overcome…
- Cocaine and TramadolTramadol and stimulants both increase the risk of seizures.
Unsafe
11- Cocaine and 2C-T-xCocaine and 2c-t-x both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in…
- Cocaine and 5-MeO-xxTThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because…
- Cocaine and AlcoholCocaine can decrease some of the intoxicating effects of alcohol, causing some people to drink more than they otherwise would, which leads to greater…
- Cocaine and DOxThe combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought…
- Cocaine and DXMBoth substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues
- Cocaine and FentanylA speedball in current form. The stimulant masks how sedated you are, so you dose again; cocaine then clears in under an hour while fentanyl is still…
- Cocaine and MethadoneBoth prolong the QT interval, and methadone's QT effect is dose-dependent and associated with a roughly four-fold rise in sudden cardiac death…
- Cocaine and MethamphetamineTwo strong stimulants with heavily overlapping cardiovascular effects and mismatched durations — cocaine is gone in under an hour, methamphetamine is…
- Cocaine and NBOMesCocaine and NBOMes both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in…
- Cocaine and PCPThis combination can easily lead to hypermanic states
- Cocaine and PregabalinThere is a significant risk of seizures from this combination. Stimulants increase respiration rate, allowing for a higher dose of sedatives than…
Caution
15- Cocaine and 2C-xThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because…
- Cocaine and AmphetaminesThis combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine…
- Cocaine and CaffeineBoth stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.
- Cocaine and CannabisStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Cocaine and DiphenhydramineStimulants increase respiration rate allowing for a higher dose of sedatives than normal. If cocaine wears off first, recreational dosages of DPH may…
- Cocaine and DMTStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Cocaine and GHB / GBLStimulants increase respiration rate allowing for a higher dose of sedatives than normal. If the stimulant wears off first the opiate may overcome…
- Cocaine and KetamineNo unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this…
- Cocaine and LSDStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Cocaine and MDMACocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.
- Cocaine and MephedroneStacking stimulants multiplies cardiovascular strain — raised heart rate, blood pressure and arrhythmia risk — without a proportionate increase in…
- Cocaine and MescalineThe focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- Cocaine and MushroomsStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Cocaine and MXEStimulants taken with MXE can lead to hypermanic states much more easily, especially if sleep is avoided.
- Cocaine and NicotineDocumented synergistic cardiovascular strain: animal work shows nicotine after cocaine produces markedly greater increases in cardiac workload than…
Low / synergy
1Low / decrease
2Low / no synergy
4Checking more than one?
This page rates Cocaine against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Cocaine in the checkerOther stimulants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.