Mixing GHB / GBL and Methadone
- GHB / GBL also called
- ghb, gbl, liquid ecstasy
- Methadone also called
- dolophine, methadose, done
Dangerous
The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix GHB / GBL and Methadone?
High risk of death or life-changing injury. Do not combine.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.
- Methadone
- Long-acting — outlasts its own effects by many hours
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.