Mixing Methadone and Pregabalin
- Methadone also called
- dolophine, methadose, done
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba
Dangerous
High risk of death or life-changing injury. Do not combine.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Methadone and Pregabalin?
High risk of death or life-changing injury. Do not combine.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.
- Methadone
- Long-acting — outlasts its own effects by many hours
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.