Combination

Mixing Ketamine and Pregabalin

DissociativeDepressant
Ketamine also called
ket, special k, kitty, kittens
Pregabalin also called
lyrica, pregablin, gabapentin, gaba
Verdict

Caution

Pregabalin and ketamine may synergize and increase each other's negative side effects such as nausea, dizziness, and loss of consciousness. Caution is advised for beyond medical dosages due to seizure concerns, and medical dosages for individuals with higher risk seizure profiles and or behavior.

Risk / Headspace

The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.

Can you mix Ketamine and Pregabalin?

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.