Combination
Mixing Fentanyl and Pregabalin
OpioidDepressant
- Fentanyl also called
- fent, fentanil, carfentanil, nitazene, nitazenes
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba
Verdict
Dangerous
Gabapentinoids carry an FDA respiratory-depression warning specifically for combination with opioids, and pregabalin appears in a rising share of opioid deaths. The sedation peaks late.
Risk / Physical
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Fentanyl and Pregabalin?
High risk of death or life-changing injury. Do not combine.
- Fentanyl
- Synthetic — potent by micrograms, unevenly mixed
- FDA Warns of Respiratory Depression With Gabapentinoids. https://www.neurologylive.com/view/fda-warns-about-respiratory-depression-with-gabapentinoids
- Gabapentin and Pregabalin May Increase Risk of Respiratory Depression. University of Utah Health. https://pharmacyservices.utah.edu/alerts/2019/12/gabapentin-and-pregabalin-may-increase-risk-of-respiratory-depression
- Deaths related to the combination of pregabalin and other drugs of abuse. https://www.sciencedirect.com/science/article/abs/pii/S2352007822003316
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Pregabalin withWhat not to mix with Pregabalin →
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.