Combination
Mixing Pregabalin and SSRIs
DepressantAntidepressant
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba
- SSRIs also called
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
Verdict
Caution
Additive sedation and dizziness. No serotonergic interaction, but the combined impairment is more than people expect from a prescribed pair.
Risk / Physical
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Pregabalin and SSRIs?
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
- FDA Warns of Respiratory Depression With Gabapentinoids. https://www.neurologylive.com/view/fda-warns-about-respiratory-depression-with-gabapentinoids
- Gabapentin and Pregabalin May Increase Risk of Respiratory Depression. University of Utah Health. https://pharmacyservices.utah.edu/alerts/2019/12/gabapentin-and-pregabalin-may-increase-risk-of-respiratory-depression
- Deaths related to the combination of pregabalin and other drugs of abuse. https://www.sciencedirect.com/science/article/abs/pii/S2352007822003316
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Pregabalin withWhat not to mix with Pregabalin →
Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.