Substance
What not to mix with Ibuprofen
Analgesic
Also calledadvil, motrin, nurofen, nsaid, nsaids
Summary
Ibuprofen is checked against 40 other substances — 1 unsafe and 3 caution.
Unsafe
1Caution
3- Ibuprofen and AlcoholBoth irritate the stomach lining and both stress the kidneys. Together they raise the risk of gastrointestinal bleeding and ulcers, and of acute…
- Ibuprofen and MDMAMDMA can cause hyperthermia, dehydration and, rarely, rhabdomyolysis — all of which stress the kidneys. NSAIDs reduce renal blood flow, so ibuprofen…
- Ibuprofen and SSRIsSSRIs deplete platelet serotonin and impair clotting; NSAIDs damage the gastric mucosa. Combined, they measurably increase the risk of upper…
Low / no synergy
36Checking more than one?
This page rates Ibuprofen against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Ibuprofen in the checkerOther analgesics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.