Combination

Mixing Amphetamines and Caffeine

StimulantStimulant
Amphetamines also called
adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
Caffeine also called
coffee, energy drink, espresso, pre-workout
Verdict

Caution

This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.

Risk / Physical

The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.

Can you mix Amphetamines and Caffeine?

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

Amphetamines
Prescription and street speed — Adderall, dexamphetamine
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.