Substance
What not to mix with Amphetamines
StimulantDrug class
Also calledadderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
Prescription and street speed — Adderall, dexamphetamine
Summary
Amphetamines is checked against 40 other substances — 3 dangerous, 7 unsafe and 23 caution.
Dangerous
3- Amphetamines and AMTHigh risk of death or life-changing injury. Do not combine.
- Amphetamines and MAOIsMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive…
- Amphetamines and TramadolTramadol and stimulants both increase the risk of seizures.
Unsafe
7- Amphetamines and 2C-T-xStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe…
- Amphetamines and 5-MeO-xxTThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because…
- Amphetamines and DOxThe combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to…
- Amphetamines and DXMBoth substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
- Amphetamines and NBOMesAmphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in…
- Amphetamines and PCPThis combination can easily lead to hypermanic states
- Amphetamines and PregabalinThere is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than…
Caution
23- Amphetamines and 2C-xThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because…
- Amphetamines and AlcoholDrinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This…
- Amphetamines and BuprenorphineStimulants increase respiration rate, which can allow for a higher dose of opiates normal . If the stimulant wears off first then the opiate may…
- Amphetamines and CaffeineThis combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater…
- Amphetamines and CannabisStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Amphetamines and CocaineThis combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine…
- Amphetamines and CodeineStimulants increase respiration rate, which can allow for a higher dose of opiates normal . If the stimulant wears off first then the opiate may…
- Amphetamines and DiphenhydramineAmphetamines as a stimulant may mask some of the negative side effects of DPH, leading to delusions of sobriety which has additional concern in…
- Amphetamines and DMTStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Amphetamines and FentanylStimulants increase respiration rate, which can allow for a higher dose of opiates normal . If the stimulant wears off first then the opiate may…
- Amphetamines and GHB / GBLStimulants increase respiration rate allowing for a higher dose of sedatives than normal. If the stimulant wears off first the opiate may overcome…
- Amphetamines and KetamineNo unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this…
- Amphetamines and KratomStimulants increase respiration rate, which can allow for a higher dose of opiates normal . If the stimulant wears off first then the opiate may…
- Amphetamines and LSDStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Amphetamines and MDMAThis combination of stimulants will increase strain on the heart, may cause some physical discomfort, and has the chance to cause cardiovascular…
- Amphetamines and MephedroneAdditive cardiovascular and neurotoxic strain from two stimulants, with a long, heavily-redosed session the typical pattern.
- Amphetamines and MescalineThe focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- Amphetamines and MethadoneStimulants increase respiration rate, which can allow for a higher dose of opiates normal . If the stimulant wears off first then the opiate may…
- Amphetamines and MethamphetamineRoughly the same molecule doing the same thing, so this is mostly a redose question wearing a combination's clothes. Methamphetamine is about twice…
- Amphetamines and MushroomsStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Amphetamines and MXERisk of tachycardia, hypertension, and manic states
- Amphetamines and NicotineBoth drive sympathetic activation, so heart rate and blood pressure rise more than with either alone. Nicotine cravings and consumption also increase…
- Amphetamines and OpioidsStimulants increase respiration rate, which can allow for a higher dose of opiates normal . If the stimulant wears off first then the opiate may…
Low / synergy
1Low / decrease
1Low / no synergy
5Checking more than one?
This page rates Amphetamines against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Amphetamines in the checkerOther stimulants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.