Combination

Mixing Amphetamines and Codeine

StimulantOpioid
Amphetamines also called
adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
Codeine also called
lean, purple drank, co-codamol, dihydrocodeine
Verdict

Caution

Stimulants increase respiration rate, which can allow for a higher dose of opiates normal . If the stimulant wears off first then the opiate may overcome the individual and cause respiratory arrest.

Risk / Physical

The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.

Can you mix Amphetamines and Codeine?

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.

Amphetamines
Prescription and street speed — Adderall, dexamphetamine
Codeine
Weak, but metabolised unpredictably between people
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.