Mixing Diphenhydramine and GHB / GBL
- Diphenhydramine also called
- benadryl, dph, sleep aid, zzzquil, unisom
- GHB / GBL also called
- ghb, gbl, liquid ecstasy
Dangerous
Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and unconsciousness. The interaction will cause greater inhibition and risk of injury. If the user falls unconscious it is strongly recommended to put them into the recovery position and monitor breathing.
This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.
Can you mix Diphenhydramine and GHB / GBL?
High risk of death or life-changing injury. Do not combine.
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
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Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.