Mixing Diphenhydramine and Tramadol
- Diphenhydramine also called
- benadryl, dph, sleep aid, zzzquil, unisom
- Tramadol also called
- tram, ultram
Dangerous
Both drugs increase the risk of serotonin syndrome. While at medical dosages, this is unlikely to be of concern, recreational doses should be avoided. Diphenhydramine may increase tramadol’s seizure risk.
This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.
Can you mix Diphenhydramine and Tramadol?
High risk of death or life-changing injury. Do not combine.
- Tramadol
- Opioid plus serotonin reuptake inhibition, and seizure risk
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.