Combination
Mixing GHB / GBL and Kratom
DepressantOpioid
- GHB / GBL also called
- ghb, gbl, liquid ecstasy
- Kratom also called
- mitragynine, mitragyna, mitragyna speciosa, krat
Verdict
Dangerous
GHB's dose-response curve is steep enough to be dangerous on its own; an opioid on top removes the margin. Unrousable sedation with vomiting is the standard presentation, and aspiration is the usual mechanism of death.
Risk / Physical
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix GHB / GBL and Kratom?
High risk of death or life-changing injury. Do not combine.
- Kratom
- Partial agonist — a ceiling other opioids do not have
- Respiratory effects of oral mitragynine and oxycodone in a rodent model. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671979/
- Dangerous Kratom Drug Interactions: Benzos, Alcohol, and More. Bicycle Health. https://www.bicyclehealth.com/kratom/dangerous-kratom-drug-interactions
- The Associations of Kratom (Mitragynine), Opioids, Other Substances, and Sociodemographic Variables to Drug Intoxication-related Mortality. https://pubmed.ncbi.nlm.nih.gov/39560283/
- Presence of kratom in opioid overdose deaths: findings from coroner postmortem toxicological report. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806006/
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.