Mixing Benzodiazepines and Kratom
- Benzodiazepines also called
- benzodiazepine, benzos, benzo, xanax, alprazolam, valium
- Kratom also called
- mitragynine, mitragyna, mitragyna speciosa, krat
Dangerous
The highest-risk kratom combination, ahead of alcohol. Benzodiazepines suppress breathing through GABA-A while kratom works the opioid receptor, and the two together comfortably clear kratom's partial-agonist ceiling. Kratom's long, uneven absorption means the peak can land well after you have stopped paying attention to it.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Benzodiazepines and Kratom?
High risk of death or life-changing injury. Do not combine.
- Kratom
- Partial agonist — a ceiling other opioids do not have
- Respiratory effects of oral mitragynine and oxycodone in a rodent model. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671979/
- Dangerous Kratom Drug Interactions: Benzos, Alcohol, and More. Bicycle Health. https://www.bicyclehealth.com/kratom/dangerous-kratom-drug-interactions
- The Associations of Kratom (Mitragynine), Opioids, Other Substances, and Sociodemographic Variables to Drug Intoxication-related Mortality. https://pubmed.ncbi.nlm.nih.gov/39560283/
- Presence of kratom in opioid overdose deaths: findings from coroner postmortem toxicological report. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806006/
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.