Combination

Mixing Lithium and Tramadol

OtherOpioid
Lithium also called
lithium carbonate, lithobid, mood stabilizer
Tramadol also called
tram, ultram
Verdict

Dangerous

Tramadol and Lithium both increase the risk of seizures and serotonin syndrome.

Risk / Physical

The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.

Can you mix Lithium and Tramadol?

High risk of death or life-changing injury. Do not combine.

Tramadol
Opioid plus serotonin reuptake inhibition, and seizure risk
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

Lithium withWhat not to mix with Lithium →
Tramadol withWhat not to mix with Tramadol →
All combinations →

Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.