Substance
What not to mix with Lithium
Other
Also calledlithium carbonate, lithobid, mood stabilizer
Summary
Lithium is checked against 40 other substances — 15 dangerous, 1 unsafe and 13 caution.
Dangerous
15- Lithium and 2C-T-xThere are a large number of reports indicating a high seizure and psychosis risk from this combination.
- Lithium and 2C-xThere are a large number of reports indicating a high seizure and psychosis risk from this combination.
- Lithium and 5-MeO-xxTLithium taken alongside classic 5-HT2A psychedelics is associated with seizures — in an analysis of user reports, 47% of lithium-plus-psychedelic…
- Lithium and AMTAMT is both a psychedelic and a stimulant, and lithium plus classic psychedelics carries a well-documented seizure risk. Do not combine.
- Lithium and DMTThere are a large number of reports indicating a high seizure and psychosis risk from this combination.
- Lithium and DOxThere are a large number of reports indicating a high seizure and psychosis risk from this combination.
- Lithium and DXMThere is a risk of serotonin syndrome when combining Lithium with DXM.
- Lithium and LSDThere are a large number of reports indicating a high seizure and psychosis risk from this combination.
- Lithium and MDMAHigh risk of serotonin syndrome
- Lithium and MephedroneLithium plus MDMA-like releasers is rated dangerous for the same reason lithium plus MDMA is: serotonergic overload against lithium's effect on…
- Lithium and MescalineThere are a large number of reports indicating a high seizure and psychosis risk from this combination.
- Lithium and MushroomsThere are a large number of reports indicating a high seizure and psychosis risk from this combination.
- Lithium and MXEThere is a risk of serotonin syndrome when combining Lithium with MXE, as Lithium can induce serotonin syndrome in conjunction with other…
- Lithium and NBOMesThere are a large number of reports indicating a high seizure and psychosis risk from this combination.
- Lithium and TramadolTramadol and Lithium both increase the risk of seizures and serotonin syndrome.
Unsafe
1Caution
13- Lithium and AlcoholDehydration from drinking concentrates lithium and can raise blood levels toward the toxic range, and the two are additively impairing. Vomiting or…
- Lithium and BuprenorphineNo direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that…
- Lithium and CaffeineCaffeine increases renal lithium excretion, so heavy coffee or energy-drink use lowers blood lithium levels — and abruptly stopping caffeine can push…
- Lithium and CodeineNo direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that…
- Lithium and DiphenhydramineThere is a concern of serotonin syndrome at higher dosages of this combination. Caution is recommended in restricting diphenhydramine to medical…
- Lithium and FentanylNo direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that…
- Lithium and GHB / GBLAdditive sedation and impairment, plus dehydration risk affecting lithium levels. GHB's narrow dose window is the dominant danger here.
- Lithium and KratomNo direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that…
- Lithium and MAOIsBoth raise serotonergic tone; combined use raises the risk of serotonin syndrome. This combination is sometimes used under psychiatric supervision…
- Lithium and MethadoneNo direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that…
- Lithium and OpioidsNo direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that…
- Lithium and PCPBoth affect neuronal excitability and lithium narrows the seizure threshold. Dissociative interactions with lithium are inconsistently reported…
- Lithium and PregabalinAdditive sedation and dizziness. No direct interaction on lithium levels, but both impair coordination.
Low / decrease
1Low / no synergy
10Checking more than one?
This page rates Lithium against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Lithium in the checkerEducational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.