Combination

Mixing MAOIs and MDMA

AntidepressantEmpathogen
MAOIs also called
maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
MDMA also called
molly, ecstasy, ecstacy, xtc, mandy, pills
Verdict

Dangerous

MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with MDMA will lead to hypertensive crises.

Risk / Physical + headspace

This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.

Can you mix MAOIs and MDMA?

High risk of death or life-changing injury. Do not combine.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

MAOIs withWhat not to mix with MAOIs →
MDMA withWhat not to mix with MDMA →
All combinations →

Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.