Substance
What not to mix with 2C-T-x
PsychedelicDrug class
Also called2c-t-2, 2c-t-7, 2c-t-21
Summary
2C-T-x is checked against 40 other substances — 3 dangerous, 5 unsafe and 12 caution.
Dangerous
3Unsafe
5- 2C-T-x and AmphetaminesStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe…
- 2C-T-x and CocaineCocaine and 2c-t-x both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in…
- 2C-T-x and DXMRisk of serious physical or psychological harm. Not recommended under any circumstances.
- 2C-T-x and MethamphetamineStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe…
- 2C-T-x and TramadolRisk of serious physical or psychological harm. Not recommended under any circumstances.
Caution
12- 2C-T-x and 2C-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and 5-MeO-xxTBoth classes of compounds can be unpredictable alone
- 2C-T-x and CannabisCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- 2C-T-x and DiphenhydramineAdditive confusion and physical discomfort; diphenhydramine tends to make an already nausea-prone psychedelic worse.
- 2C-T-x and DOxCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and MAOIsMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably, which could be dangerous given the unpredictability of the…
- 2C-T-x and MDMACarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and MephedroneAdditive stimulation, overstimulation and nausea; 2C-T-x compounds are unpredictable at the best of times.
- 2C-T-x and MescalineCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and MXECarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and NBOMesCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and PregabalinSedation blunts and muddles the psychedelic effect, which invites redosing the psychedelic. Consistent with how pregabalin is rated against other…
Low / synergy
5Low / decrease
4Low / no synergy
11Checking more than one?
This page rates 2C-T-x against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open 2C-T-x in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.