Substance
What not to mix with NBOMes
PsychedelicDrug class
Also called25i, 25i-nbome, 25c-nbome, 25b-nbome, n-bomb, nbome
Summary
NBOMes is checked against 40 other substances — 3 dangerous, 5 unsafe and 12 caution.
Dangerous
3- NBOMes and AMTHigh risk of death or life-changing injury. Do not combine.
- NBOMes and LithiumThere are a large number of reports indicating a high seizure and psychosis risk from this combination.
- NBOMes and PregabalinNBOMes and pregabalin are reported to have significant seizure concerns that are likely to increase in combination. Therapeutic dosages of pregabalin…
Unsafe
5- NBOMes and AmphetaminesAmphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in…
- NBOMes and CocaineCocaine and NBOMes both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in…
- NBOMes and DXMRisk of serious physical or psychological harm. Not recommended under any circumstances.
- NBOMes and MethamphetamineAmphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in…
- NBOMes and TramadolTramadol is well known to lower seizure threshold and NBOMes have also shown a tendency to cause severe seizures
Caution
12- NBOMes and 2C-T-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and 2C-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and 5-MeO-xxTThe 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMes are known to be unpredictable even alone. This combination…
- NBOMes and CaffeineCaffeine can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle…
- NBOMes and CannabisCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- NBOMes and DiphenhydramineAt 25-50mg, DPH may assist with side effects of the NBOMe drugs such as nausea and anxiety. At higher dosages, the combination of a deliriant (DPH)…
- NBOMes and DOxCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and MAOIsMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably
- NBOMes and MDMACarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and MephedroneNBOMes are already vasoconstrictive and stimulating; adding a cathinone stimulant compounds cardiovascular strain and seizure risk.
- NBOMes and MescalineCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and MXEAs an NMDA antagonist MXE potentiates NBOMes which can be unpleasantly intense
Low / synergy
6Low / decrease
4Low / no synergy
10Checking more than one?
This page rates NBOMes against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open NBOMes in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.