Substance
What not to mix with 5-MeO-xxT
PsychedelicDrug class
Also called5-meo-dmt, 5-meo-mipt, 5-meo-dipt, foxy, toad
Summary
5-MeO-xxT is checked against 40 other substances — 4 dangerous, 5 unsafe and 10 caution.
Dangerous
4- 5-MeO-xxT and AMTHigh risk of death or life-changing injury. Do not combine.
- 5-MeO-xxT and LithiumLithium taken alongside classic 5-HT2A psychedelics is associated with seizures — in an analysis of user reports, 47% of lithium-plus-psychedelic…
- 5-MeO-xxT and MAOIsHigh risk of death or life-changing injury. Do not combine.
- 5-MeO-xxT and PCPHigh risk of death or life-changing injury. Do not combine.
Unsafe
5- 5-MeO-xxT and AmphetaminesThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because…
- 5-MeO-xxT and CocaineThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because…
- 5-MeO-xxT and DXMLittle information exists about this combination.
- 5-MeO-xxT and MethamphetamineThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because…
- 5-MeO-xxT and TramadolRisk of serious physical or psychological harm. Not recommended under any circumstances.
Caution
10- 5-MeO-xxT and 2C-T-xBoth classes of compounds can be unpredictable alone
- 5-MeO-xxT and 2C-xThe 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
- 5-MeO-xxT and CannabisCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- 5-MeO-xxT and DiphenhydramineDeliriant effects combined with an intense, short psychedelic make for a disorienting and hard-to-manage experience.
- 5-MeO-xxT and DOxThe 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
- 5-MeO-xxT and MDMASome of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care
- 5-MeO-xxT and MephedroneBoth are serotonergic; combining them raises the risk of serotonin syndrome alongside heavy overstimulation.
- 5-MeO-xxT and MescalineThe 5-MeO class of tryptamines can be unpredictable in their interactions
- 5-MeO-xxT and NBOMesThe 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMes are known to be unpredictable even alone. This combination…
- 5-MeO-xxT and PregabalinCaution should be given due to 5-MeO-xxT drugs stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the…
Low / synergy
6Low / decrease
4Low / no synergy
11Checking more than one?
This page rates 5-MeO-xxT against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open 5-MeO-xxT in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.