Substance
What not to mix with AMT
Psychedelic
Also calledalpha-methyltryptamine, alphamethyltryptamine, indopan, monase
Summary
AMT is checked against 40 other substances — 17 dangerous and 6 caution.
Dangerous
17- AMT and 2C-T-xHigh risk of death or life-changing injury. Do not combine.
- AMT and 2C-xHigh risk of death or life-changing injury. Do not combine.
- AMT and 5-MeO-xxTHigh risk of death or life-changing injury. Do not combine.
- AMT and AmphetaminesHigh risk of death or life-changing injury. Do not combine.
- AMT and CocaineHigh risk of death or life-changing injury. Do not combine.
- AMT and DOxHigh risk of death or life-changing injury. Do not combine.
- AMT and DXMHigh risk of death or life-changing injury. Do not combine.
- AMT and LithiumAMT is both a psychedelic and a stimulant, and lithium plus classic psychedelics carries a well-documented seizure risk. Do not combine.
- AMT and MAOIsaMT is an MAOI on its own. Using enzyme inhibitors can greatly reduce predictability of effects.
- AMT and MDMAHigh risk of death or life-changing injury. Do not combine.
- AMT and MescalineHigh risk of death or life-changing injury. Do not combine.
- AMT and MethamphetamineHigh risk of death or life-changing injury. Do not combine.
- AMT and MXEHigh risk of death or life-changing injury. Do not combine.
- AMT and NBOMesHigh risk of death or life-changing injury. Do not combine.
- AMT and PCPHigh risk of death or life-changing injury. Do not combine.
- AMT and SSRIsHigh risk of death or life-changing injury. Do not combine.
- AMT and TramadolHigh risk of death or life-changing injury. Do not combine.
Caution
6- AMT and AlcoholaMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable
- AMT and CaffeineHigh doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some…
- AMT and CannabisCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Small amounts can reduce nausea with aMT but take care.
- AMT and DiphenhydramineAdditive confusion, plus anticholinergic suppression of sweating against AMT's stimulant load on body temperature.
- AMT and MephedroneBoth are serotonin-releasing stimulants. Combined, they carry real serotonin syndrome and cardiovascular risk.
- AMT and PregabalinMixed stimulant-psychedelic against a sedative — unpredictable, and the sedation masks how much AMT is on board.
Low / synergy
5Low / decrease
2Low / no synergy
10Checking more than one?
This page rates AMT against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open AMT in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.