Combination

Mixing Alcohol and MAOIs

DepressantAntidepressant
Alcohol also called
booze, beer, wine, liquor, ethanol, etoh
MAOIs also called
maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
Verdict

Unsafe

Tyramine found in many alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.

Risk / Physical

The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.

Can you mix Alcohol and MAOIs?

Risk of serious physical or psychological harm. Not recommended under any circumstances.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

Alcohol withWhat not to mix with Alcohol →
MAOIs withWhat not to mix with MAOIs →
All combinations →

Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.