Combination

Mixing Amphetamines and Opioids

StimulantOpioid
Amphetamines also called
adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
Opioids also called
opiate, opiates, opioid, heroin, dope, smack
Verdict

Caution

Stimulants increase respiration rate, which can allow for a higher dose of opiates normal . If the stimulant wears off first then the opiate may overcome the individual and cause respiratory arrest.

Risk / Physical

The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.

Can you mix Amphetamines and Opioids?

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

Amphetamines
Prescription and street speed — Adderall, dexamphetamine
Opioids
Full agonists — heroin, oxycodone, morphine
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

Open this in the checker

Related combinations

All combinations →

Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.