Mixing Benzodiazepines and Opioids
- Benzodiazepines also called
- benzodiazepine, benzos, benzo, xanax, alprazolam, valium
- Opioids also called
- opiate, opiates, opioid, heroin, dope, smack
Dangerous
Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Benzodiazepines and Opioids?
High risk of death or life-changing injury. Do not combine.
- Opioids
- Full agonists — heroin, oxycodone, morphine
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.