Combination
Mixing Kratom and Pregabalin
OpioidDepressant
- Kratom also called
- mitragynine, mitragyna, mitragyna speciosa, krat
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba
Verdict
Unsafe
Gabapentinoids potentiate opioid respiratory depression and carry an FDA warning for exactly this. The sedation arrives later than you expect and lasts longer.
Risk / Physical
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Kratom and Pregabalin?
Risk of serious physical or psychological harm. Not recommended under any circumstances.
- Kratom
- Partial agonist — a ceiling other opioids do not have
- FDA Warns of Respiratory Depression With Gabapentinoids. https://www.neurologylive.com/view/fda-warns-about-respiratory-depression-with-gabapentinoids
- Gabapentin and Pregabalin May Increase Risk of Respiratory Depression. University of Utah Health. https://pharmacyservices.utah.edu/alerts/2019/12/gabapentin-and-pregabalin-may-increase-risk-of-respiratory-depression
- Deaths related to the combination of pregabalin and other drugs of abuse. https://www.sciencedirect.com/science/article/abs/pii/S2352007822003316
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Pregabalin withWhat not to mix with Pregabalin →
Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.