Substance
What not to mix with Benzodiazepines
DepressantDrug class
Also calledbenzodiazepine, benzos, benzo, xanax, alprazolam, valium
Summary
Benzodiazepines is checked against 40 other substances — 9 dangerous, 3 unsafe and 4 caution.
Dangerous
9- Benzodiazepines and AlcoholEthanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very…
- Benzodiazepines and CodeineAdditive respiratory depression, made worse by codeine's unpredictable conversion. A dose that was fine last time can convert very differently…
- Benzodiazepines and FentanylThe single most lethal pairing in current overdose data. Benzodiazepines remove the arousal response you would otherwise rely on to keep breathing…
- Benzodiazepines and GHB / GBLThe two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is…
- Benzodiazepines and KratomThe highest-risk kratom combination, ahead of alcohol. Benzodiazepines suppress breathing through GABA-A while kratom works the opioid receptor, and…
- Benzodiazepines and MethadoneAdditive respiratory depression against methadone's long, invisible tail. The combination is well documented in methadone-treatment mortality data…
- Benzodiazepines and OpioidsCentral nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other…
- Benzodiazepines and PregabalinAdditive respiratory depression between two CNS depressants, and a combination that appears repeatedly in overdose death reports. Both also cause…
- Benzodiazepines and TramadolCentral nervous system- and/or respiratory-depressant effects may be additively or synergistically present. Vomit aspiration is a risk when passed…
Unsafe
3- Benzodiazepines and BuprenorphineThe main cause of death in people taking buprenorphine. The ceiling does not extend to GABA-A depression. Prescribed benzodiazepines alongside…
- Benzodiazepines and DiphenhydramineBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Benzodiazepines and PCPBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
Caution
4- Benzodiazepines and DXMSmall doses of benzos can end a bad trip, but both substances potentiate the ataxia and sedation caused by the other and this can lead to unexpected…
- Benzodiazepines and KetamineBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Benzodiazepines and MelatoninAdditive CNS depression — increased drowsiness, confusion, impaired coordination and memory. The combination is common and rarely dangerous at normal…
- Benzodiazepines and MXEBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the…
Low / synergy
1Low / decrease
18Low / no synergy
5Checking more than one?
This page rates Benzodiazepines against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Benzodiazepines in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.