Combination
Mixing Kratom and MAOIs
OpioidAntidepressant
- Kratom also called
- mitragynine, mitragyna, mitragyna speciosa, krat
- MAOIs also called
- maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
Verdict
Dangerous
Mitragynine has monoamine activity and MAOIs block the breakdown of exactly what it releases. Hypertensive and serotonergic reactions are both plausible. This includes ayahuasca and syrian rue, not only prescription MAOIs.
Risk / Physical
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Kratom and MAOIs?
High risk of death or life-changing injury. Do not combine.
- Kratom
- Partial agonist — a ceiling other opioids do not have
- Respiratory effects of oral mitragynine and oxycodone in a rodent model. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671979/
- Dangerous Kratom Drug Interactions: Benzos, Alcohol, and More. Bicycle Health. https://www.bicyclehealth.com/kratom/dangerous-kratom-drug-interactions
- The Associations of Kratom (Mitragynine), Opioids, Other Substances, and Sociodemographic Variables to Drug Intoxication-related Mortality. https://pubmed.ncbi.nlm.nih.gov/39560283/
- Presence of kratom in opioid overdose deaths: findings from coroner postmortem toxicological report. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806006/
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.