Substance
What not to mix with Mephedrone
Stimulant
Also called4-mmc, 4mmc, meow, m-cat, 4-methylmethcathinone, bath salts
Summary
Mephedrone is checked against 40 other substances — 6 dangerous, 1 unsafe and 25 caution.
Dangerous
6- Mephedrone and DiphenhydramineThere is a high risk of serotonin syndrome at recreational dosages. Both can dull each other's effects, so if one wears off before the other it's…
- Mephedrone and DXMRisk of serotonin syndrome as both drugs raise serotonin levels. In addition to concerns of high blood pressure and unnecessary strain on the heart…
- Mephedrone and LithiumLithium plus MDMA-like releasers is rated dangerous for the same reason lithium plus MDMA is: serotonergic overload against lithium's effect on…
- Mephedrone and MAOIsMephedrone releases serotonin, dopamine and noradrenaline. With an MAOI blocking their breakdown, this risks hypertensive crisis and serotonin…
- Mephedrone and MDMARisk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of…
- Mephedrone and TramadolThere is a high risk of serotonin syndrome and seizures at recreational dosages. Both substances affect the heart and may lead to further dangerous…
Unsafe
1Caution
25- Mephedrone and 2C-T-xAdditive stimulation, overstimulation and nausea; 2C-T-x compounds are unpredictable at the best of times.
- Mephedrone and 2C-xAdditive stimulation and cardiovascular strain on top of a phenethylamine that is itself somewhat stimulating.
- Mephedrone and 5-MeO-xxTBoth are serotonergic; combining them raises the risk of serotonin syndrome alongside heavy overstimulation.
- Mephedrone and AlcoholAlcohol enhances mephedrone's stimulant effect and markedly increases the urge to redose. Animal work also shows the combination produces broader…
- Mephedrone and AmphetaminesAdditive cardiovascular and neurotoxic strain from two stimulants, with a long, heavily-redosed session the typical pattern.
- Mephedrone and AMTBoth are serotonin-releasing stimulants. Combined, they carry real serotonin syndrome and cardiovascular risk.
- Mephedrone and BuprenorphineStimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and…
- Mephedrone and CaffeineThis combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and great…
- Mephedrone and CocaineStacking stimulants multiplies cardiovascular strain — raised heart rate, blood pressure and arrhythmia risk — without a proportionate increase in…
- Mephedrone and CodeineStimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and…
- Mephedrone and DOxThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops, in addition to the possible negative side effects…
- Mephedrone and FentanylStimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and…
- Mephedrone and GHB / GBLBoth can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction. Both substances…
- Mephedrone and KetamineThe stimulant masks how dissociated you are, which is how people redose ketamine past the point they intended.
- Mephedrone and KratomStimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and…
- Mephedrone and LSDThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops, in addition to the possible negative side effects…
- Mephedrone and MescalineAdditive stimulation and cardiovascular strain, with amplified anxiety a common outcome.
- Mephedrone and MethadoneStimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and…
- Mephedrone and MethamphetamineAdditive cardiovascular and neurotoxic strain from two stimulants, with a long, heavily-redosed session the typical pattern.
- Mephedrone and MXEThe stimulant masks the depth of dissociation and encourages redosing; additive cardiovascular strain.
- Mephedrone and NBOMesNBOMes are already vasoconstrictive and stimulating; adding a cathinone stimulant compounds cardiovascular strain and seizure risk.
- Mephedrone and NicotineAdditive sympathetic stimulation and cardiovascular strain, with heavily increased smoking over a redosing session.
- Mephedrone and OpioidsStimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and…
- Mephedrone and PCPStimulant against dissociative — unpredictable, with additive cardiovascular strain and impaired judgement.
- Mephedrone and SSRIsSSRIs blunt mephedrone's effects (which invites redosing) while raising serotonin syndrome risk. The blunting is the more common outcome; the…
Low / synergy
4Low / decrease
1Low / no synergy
3Checking more than one?
This page rates Mephedrone against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Mephedrone in the checkerOther stimulants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.