Substance
What not to mix with Methamphetamine
Stimulant
Also calledmeth, crystal, crystal meth, ice, tina, shard
Roughly twice as potent, and lasts three to four times as long
Summary
Methamphetamine is checked against 40 other substances — 3 dangerous, 15 unsafe and 15 caution.
Dangerous
3- Methamphetamine and AMTHigh risk of death or life-changing injury. Do not combine.
- Methamphetamine and MAOIsMethamphetamine releases noradrenaline, dopamine and serotonin; an MAOI prevents their breakdown. Hypertensive crisis and serotonin syndrome are both…
- Methamphetamine and TramadolTramadol and stimulants both increase the risk of seizures.
Unsafe
15- Methamphetamine and 2C-T-xStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe…
- Methamphetamine and 5-MeO-xxTThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because…
- Methamphetamine and BuprenorphineA stimulant masking opioid sedation is how people miss the point at which they are overdosing. Methamphetamine's long duration means the opioid is…
- Methamphetamine and CocaineTwo strong stimulants with heavily overlapping cardiovascular effects and mismatched durations — cocaine is gone in under an hour, methamphetamine is…
- Methamphetamine and CodeineA stimulant masking opioid sedation is how people miss the point at which they are overdosing. Methamphetamine's long duration means the opioid is…
- Methamphetamine and DOxThe combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to…
- Methamphetamine and DXMBoth substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
- Methamphetamine and FentanylSame mechanism as the cocaine pairing but stretched over a much longer stimulant window, so the fentanyl is often redosed repeatedly across it. The…
- Methamphetamine and KratomA stimulant masking opioid sedation is how people miss the point at which they are overdosing. Methamphetamine's long duration means the opioid is…
- Methamphetamine and MDMABoth are releasers acting on the same neurons, and the neurotoxicity mechanisms are shared — serotonergic and dopaminergic terminals under oxidative…
- Methamphetamine and MethadoneA stimulant masking opioid sedation is how people miss the point at which they are overdosing. Methamphetamine's long duration means the opioid is…
- Methamphetamine and NBOMesAmphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in…
- Methamphetamine and OpioidsA stimulant masking opioid sedation is how people miss the point at which they are overdosing. Methamphetamine's long duration means the opioid is…
- Methamphetamine and PCPThis combination can easily lead to hypermanic states
- Methamphetamine and PregabalinThere is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than…
Caution
15- Methamphetamine and 2C-xThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because…
- Methamphetamine and AlcoholAlcohol's sedation is masked, so people drink considerably more than they otherwise would and remember less of it. Both strain the heart. The…
- Methamphetamine and AmphetaminesRoughly the same molecule doing the same thing, so this is mostly a redose question wearing a combination's clothes. Methamphetamine is about twice…
- Methamphetamine and CaffeineThis combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater…
- Methamphetamine and CannabisStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Methamphetamine and DiphenhydramineAmphetamines as a stimulant may mask some of the negative side effects of DPH, leading to delusions of sobriety which has additional concern in…
- Methamphetamine and DMTStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Methamphetamine and GHB / GBLStimulants increase respiration rate allowing for a higher dose of sedatives than normal. If the stimulant wears off first the opiate may overcome…
- Methamphetamine and KetamineNo unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this…
- Methamphetamine and LSDStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Methamphetamine and MephedroneAdditive cardiovascular and neurotoxic strain from two stimulants, with a long, heavily-redosed session the typical pattern.
- Methamphetamine and MescalineThe focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- Methamphetamine and MushroomsStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Methamphetamine and MXERisk of tachycardia, hypertension, and manic states
- Methamphetamine and SSRIsSSRIs blunt methamphetamine's effect, which invites redosing, while adding serotonin toxicity risk. Some SSRIs also inhibit CYP2D6 and slow its…
Low / synergy
1Low / decrease
1Low / no synergy
5Checking more than one?
This page rates Methamphetamine against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Methamphetamine in the checkerOther stimulants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.