Mixing Benzodiazepines and Diphenhydramine
- Benzodiazepines also called
- benzodiazepine, benzos, benzo, xanax, alprazolam, valium
- Diphenhydramine also called
- benadryl, dph, sleep aid, zzzquil, unisom
Unsafe
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely. Low medical doses are unlikely to be of concern.
This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.
Can you mix Benzodiazepines and Diphenhydramine?
Risk of serious physical or psychological harm. Not recommended under any circumstances.
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.